Critics Fear Collider Could Doom Earth
By DOUGLAS BIRCH,AP
Posted: 2008-06-29 23:04:48
Filed Under: Science News
MEYRIN, Switzerland (June 29) - The most powerful atom-smasher ever built could make some bizarre discoveries, such as invisible matter or extra dimensions in space, after it is switched on in August.
But some critics fear the Large Hadron Collider could exceed physicists' wildest conjectures: Will it spawn a black hole that could swallow Earth? Or spit out particles that could turn the planet into a hot dead clump?
The Pros and ConsMartial Trezzini, Keystone / APScientists have been working for a generation to build the Large Hadron Collider (LHC) particle collider, called the largest science experiment in history. It consists of a ring of supercooled magnets 17 miles in circumference, buried 330 feet below the French-Swiss border.
Ridiculous, say scientists at the European Organization for Nuclear Research, known by its French initials CERN - some of whom have been working for a generation on the $5.8 billion collider, or LHC.
"Obviously, the world will not end when the LHC switches on," said project leader Lyn Evans. David Francis, a physicist on the collider's huge ATLAS particle detector, smiled when asked whether he worried about black holes and hypothetical killer particles known as strangelets. "If I thought that this was going to happen, I would be well away from here," he said.
The collider basically consists of a ring of supercooled magnets 17 miles in circumference attached to huge barrel-shaped detectors. The ring, which straddles the French and Swiss border, is buried 330 feet underground.
The machine, which has been called the largest scientific experiment in history, isn't expected to begin test runs until August, and ramping up to full power could take months. But once it is working, it is expected to produce some startling findings.
Scientists plan to hunt for signs of the invisible "dark matter" and "dark energy" that make up more than 96 percent of the universe, and hope to glimpse the elusive Higgs boson, a so-far undiscovered particle thought to give matter its mass.
The collider could find evidence of extra dimensions, a boon for superstring theory, which holds that quarks, the particles that make up atoms, are infinitesimal vibrating strings.
The theory could resolve many of physics' unanswered questions, but requires about 10 dimensions - far more than the three spatial dimensions our senses experience.
The safety of the collider, which will generate energies seven times higher than its most powerful rival, at Fermilab near Chicago, has been debated for years. The physicist Martin Rees has estimated the chance of an accelerator producing a global catastrophe at one in 50 million - long odds, to be sure, but about the same as winning some lotteries.
By contrast, a CERN team this month issued a report concluding that there is "no conceivable danger" of a cataclysmic event. The report essentially confirmed the findings of a 2003 CERN safety report, and a panel of five prominent scientists not affiliated with CERN, including one Nobel laureate, endorsed its conclusions.
Critics of the LHC filed a lawsuit in a Hawaiian court in March seeking to block its startup, alleging that there was "a significant risk that ... operation of the Collider may have unintended consequences which could ultimately result in the destruction of our planet."
One of the plaintiffs, Walter L. Wagner, a physicist and lawyer, said Wednesday CERN's safety report, released June 20, "has several major flaws," and his views on the risks of using the particle accelerator had not changed.
On Tuesday, U.S. Justice Department lawyers representing the Department of Energy and the National Science Foundation filed a motion to dismiss the case.
The two agencies have contributed $531 million to building the collider, and the NSF has agreed to pay $87 million of its annual operating costs. Hundreds of American scientists will participate in the research.
The lawyers called the plaintiffs' allegations "extraordinarily speculative," and said "there is no basis for any conceivable threat" from black holes or other objects the LHC might produce. A hearing on the motion is expected in late July or August.
In rebutting doomsday scenarios, CERN scientists point out that cosmic rays have been bombarding the earth, and triggering collisions similar to those planned for the collider, since the solar system formed 4.5 billion years ago.
And so far, Earth has survived.
"The LHC is only going to reproduce what nature does every second, what it has been doing for billions of years," said John Ellis, a British theoretical physicist at CERN.
Critics like Wagner have said the collisions caused by accelerators could be more hazardous than those of cosmic rays.
Both may produce micro black holes, subatomic versions of cosmic black holes - collapsed stars whose gravity fields are so powerful that they can suck in planets and other stars.
But micro black holes produced by cosmic ray collisions would likely be traveling so fast they would pass harmlessly through the earth.
Micro black holes produced by a collider, the skeptics theorize, would move more slowly and might be trapped inside the earth's gravitational field - and eventually threaten the planet.
Ellis said doomsayers assume that the collider will create micro black holes in the first place, which he called unlikely. And even if they appeared, he said, they would instantly evaporate, as predicted by the British physicist Stephen Hawking.
As for strangelets, CERN scientists point out that they have never been proven to exist. They said that even if these particles formed inside the Collider they would quickly break down.
When the LHC is finally at full power, two beams of protons will race around the huge ring 11,000 times a second in opposite directions. They will travel in two tubes about the width of fire hoses, speeding through a vacuum that is colder and emptier than outer space.
Their trajectory will be curved by supercooled magnets - to guide the beams around the rings and prevent the packets of protons from cutting through the surrounding magnets like a blowtorch.
The paths of these beams will cross, and a few of the protons in them will collide, at a series of cylindrical detectors along the ring. The two largest detectors are essentially huge digital cameras, each weighing thousands of tons, capable of taking millions of snapshots a second.
Each year the detectors will generate 15 petabytes of data, the equivalent of a stack of CDs 12 miles tall. The data will require a high speed global network of computers for analysis.
Wagner and others filed a lawsuit to halt operation of the Relativistic Heavy Ion Collider, or RHIC, at the Brookhaven National Laboratory in New York state in 1999. The courts dismissed the suit.
The leafy campus of CERN, a short drive from the shores of Lake Geneva, hardly seems like ground zero for doomsday. And locals don't seem overly concerned. Thousands attended an open house here this spring.
"There is a huge army of scientists who know what they are talking about and are sleeping quite soundly as far as concerns the LHC," said project leader Evans.
Copyright 2008 The Associated Press. The information contained in the AP news report may not be published, broadcast, rewritten or otherwise distributed without the prior written authority of The Associated Press.
Monday, June 30, 2008
Eliminating Breast Cancer Gene From Baby
Baby to be born free of breast cancer after embryo screening
Sarah-Kate Templeton, Health Editor
A woman has conceived Britain’s first baby guaranteed to be free from hereditary breast cancer.Doctors screened out from the woman’s embryos an inherited gene that would have left the baby with a greater than 50% chance of developing the cancer.
The woman decided to have her embryos screened because her husband had tested positive for the gene and his sister, mother, grandmother and cousin have all had the cancer. The couple produced 11 embryos, of which five were found to be free from the gene. Two of these were implanted in the woman’s womb and she is now 14 weeks pregnant.
By screening out embryos carrying the gene, called BRCA-1, the couple, from London, will eliminate the hereditary disease from their lineage.
About 5% of the 44,000 cases of breast cancer diagnosed in Britain each year are estimated to be caused by the BRCA-1 and BRCA-2 genes, both of which can be detected in embryos.
Doctors say thousands of cases of breast cancer could be avoided by screening embryos using the technique called preimplantation diagnosis (PGD).
Many women who test positive for the gene have their breasts surgically removed to avoid the disease. Only one other woman – an Israeli mother-to-be – is thought to have become pregnant after undergoing the embryo screening.
The 27-year-old British mother, who asked not to be named, says that after seeing all her husband’s female relatives suffer from breast cancer, she felt she had to take action to save their children from the same plight. Any daughter born with the gene would have had a 50% to 85% chance of developing breast cancer.
She said: “For the past three generations, every single woman in my husband’s family has had breast cancer, as early as 27 and 29. We felt that, if there was a possibility of eliminating this for our children, then that was a route we had to go down.
“It has been successful for us which means we are eliminating the gene from our line.
“We had been through his sister being ill, so it was something we had seen first hand. I thought this was something I had to try because, if we had a daughter with the gene, and she was ill, I couldn’t look her in the face and say I didn’t try.”
The woman and her 28-year-old husband had to go through IVF (in vitro fertilisation) even though they are fertile, in order to create embryos that could be screened.
Tests on the 11 embryos were conducted by removing just one cell when they were three days old. Six of the embryos carried the breast cancer gene. Two embryos that were free of the gene were then implanted, resulting in a single pregnancy.
The couple have also been able to freeze two healthy embryos for future use.
The woman said she felt a responsibility to put herself through the invasive IVF procedure. “The treatment I had to go through was nothing in comparison to what I have seen members of my husband’s family go through.”
In addition to breast cancer, women carrying the gene also have a higher risk of ovarian cancer and male carriers are at greater risk of developing prostate cancer.
The couple’s doctor, Paul Serhal, medical director of the Assisted Conception Unit at University College London hospital, said the breakthrough gives parents the option of avoiding passing a high risk of breast cancer on to their children.
He said: “Women now have the option of having this treatment to avoid the potential guilty feeling of passing on this genetic abnormality to a child. This gives us the chance to eradicate this problem in families.” Serhal added: “It may be devastating psychologically and emotionally for a young woman to have her breasts removed.”
Serhal has treated other couples to create babies free from less well known cancer genes, including one that causes eye cancer and another that carries a high risk of bowel cancer.
Some critics say it is wrong to destroy embryos because there is only a chance women with the gene may develop breast cancer in adulthood. They argue that, increasingly, breast cancer can also be successfully treated.
Sarah-Kate Templeton, Health Editor
A woman has conceived Britain’s first baby guaranteed to be free from hereditary breast cancer.Doctors screened out from the woman’s embryos an inherited gene that would have left the baby with a greater than 50% chance of developing the cancer.
The woman decided to have her embryos screened because her husband had tested positive for the gene and his sister, mother, grandmother and cousin have all had the cancer. The couple produced 11 embryos, of which five were found to be free from the gene. Two of these were implanted in the woman’s womb and she is now 14 weeks pregnant.
By screening out embryos carrying the gene, called BRCA-1, the couple, from London, will eliminate the hereditary disease from their lineage.
About 5% of the 44,000 cases of breast cancer diagnosed in Britain each year are estimated to be caused by the BRCA-1 and BRCA-2 genes, both of which can be detected in embryos.
Doctors say thousands of cases of breast cancer could be avoided by screening embryos using the technique called preimplantation diagnosis (PGD).
Many women who test positive for the gene have their breasts surgically removed to avoid the disease. Only one other woman – an Israeli mother-to-be – is thought to have become pregnant after undergoing the embryo screening.
The 27-year-old British mother, who asked not to be named, says that after seeing all her husband’s female relatives suffer from breast cancer, she felt she had to take action to save their children from the same plight. Any daughter born with the gene would have had a 50% to 85% chance of developing breast cancer.
She said: “For the past three generations, every single woman in my husband’s family has had breast cancer, as early as 27 and 29. We felt that, if there was a possibility of eliminating this for our children, then that was a route we had to go down.
“It has been successful for us which means we are eliminating the gene from our line.
“We had been through his sister being ill, so it was something we had seen first hand. I thought this was something I had to try because, if we had a daughter with the gene, and she was ill, I couldn’t look her in the face and say I didn’t try.”
The woman and her 28-year-old husband had to go through IVF (in vitro fertilisation) even though they are fertile, in order to create embryos that could be screened.
Tests on the 11 embryos were conducted by removing just one cell when they were three days old. Six of the embryos carried the breast cancer gene. Two embryos that were free of the gene were then implanted, resulting in a single pregnancy.
The couple have also been able to freeze two healthy embryos for future use.
The woman said she felt a responsibility to put herself through the invasive IVF procedure. “The treatment I had to go through was nothing in comparison to what I have seen members of my husband’s family go through.”
In addition to breast cancer, women carrying the gene also have a higher risk of ovarian cancer and male carriers are at greater risk of developing prostate cancer.
The couple’s doctor, Paul Serhal, medical director of the Assisted Conception Unit at University College London hospital, said the breakthrough gives parents the option of avoiding passing a high risk of breast cancer on to their children.
He said: “Women now have the option of having this treatment to avoid the potential guilty feeling of passing on this genetic abnormality to a child. This gives us the chance to eradicate this problem in families.” Serhal added: “It may be devastating psychologically and emotionally for a young woman to have her breasts removed.”
Serhal has treated other couples to create babies free from less well known cancer genes, including one that causes eye cancer and another that carries a high risk of bowel cancer.
Some critics say it is wrong to destroy embryos because there is only a chance women with the gene may develop breast cancer in adulthood. They argue that, increasingly, breast cancer can also be successfully treated.
Friday, June 20, 2008
Genetic Engineering of Oil from Organisims
Scientists find bugs that eat waste and excrete petrol
Silicon Valley is experimenting with bacteria that have been genetically altered to provide 'renewable petroleum'
Some diesel fuel produced by genetically modified bugs
Image :1 of 3
Chris Ayres
“Ten years ago I could never have imagined I’d be doing this,” says Greg Pal, 33, a former software executive, as he squints into the late afternoon Californian sun. “I mean, this is essentially agriculture, right? But the people I talk to – especially the ones coming out of business school – this is the one hot area everyone wants to get into.”
He means bugs. To be more precise: the genetic alteration of bugs – very, very small ones – so that when they feed on agricultural waste such as woodchips or wheat straw, they do something extraordinary. They excrete crude oil.
Unbelievably, this is not science fiction. Mr Pal holds up a small beaker of bug excretion that could, theoretically, be poured into the tank of the giant Lexus SUV next to us. Not that Mr Pal is willing to risk it just yet. He gives it a month before the first vehicle is filled up on what he calls “renewable petroleum”. After that, he grins, “it’s a brave new world”.
Mr Pal is a senior director of LS9, one of several companies in or near Silicon Valley that have spurned traditional high-tech activities such as software and networking and embarked instead on an extraordinary race to make $140-a-barrel oil (£70) from Saudi Arabia obsolete. “All of us here – everyone in this company and in this industry, are aware of the urgency,” Mr Pal says.
What is most remarkable about what they are doing is that instead of trying to reengineer the global economy – as is required, for example, for the use of hydrogen fuel – they are trying to make a product that is interchangeable with oil. The company claims that this “Oil 2.0” will not only be renewable but also carbon negative – meaning that the carbon it emits will be less than that sucked from the atmosphere by the raw materials from which it is made.
LS9 has already convinced one oil industry veteran of its plan: Bob Walsh, 50, who now serves as the firm’s president after a 26-year career at Shell, most recently running European supply operations in London. “How many times in your life do you get the opportunity to grow a multi-billion-dollar company?” he asks. It is a bold statement from a man who works in a glorified cubicle in a San Francisco industrial estate for a company that describes itself as being “prerevenue”.
Inside LS9’s cluttered laboratory – funded by $20 million of start-up capital from investors including Vinod Khosla, the Indian-American entrepreneur who co-founded Sun Micro-systems – Mr Pal explains that LS9’s bugs are single-cell organisms, each a fraction of a billionth the size of an ant. They start out as industrial yeast or nonpathogenic strains of E. coli, but LS9 modifies them by custom-de-signing their DNA. “Five to seven years ago, that process would have taken months and cost hundreds of thousands of dollars,” he says. “Now it can take weeks and cost maybe $20,000.”
Because crude oil (which can be refined into other products, such as petroleum or jet fuel) is only a few molecular stages removed from the fatty acids normally excreted by yeast or E. coli during fermentation, it does not take much fiddling to get the desired result.
For fermentation to take place you need raw material, or feedstock, as it is known in the biofuels industry. Anything will do as long as it can be broken down into sugars, with the byproduct ideally burnt to produce electricity to run the plant.
The company is not interested in using corn as feedstock, given the much-publicised problems created by using food crops for fuel, such as the tortilla inflation that recently caused food riots in Mexico City. Instead, different types of agricultural waste will be used according to whatever makes sense for the local climate and economy: wheat straw in California, for example, or woodchips in the South.
Using genetically modified bugs for fermentation is essentially the same as using natural bacteria to produce ethanol, although the energy-intensive final process of distillation is virtually eliminated because the bugs excrete a substance that is almost pump-ready.
The closest that LS9 has come to mass production is a 1,000-litre fermenting machine, which looks like a large stainless-steel jar, next to a wardrobe-sized computer connected by a tangle of cables and tubes. It has not yet been plugged in. The machine produces the equivalent of one barrel a week and takes up 40 sq ft of floor space.
However, to substitute America’s weekly oil consumption of 143 million barrels, you would need a facility that covered about 205 square miles, an area roughly the size of Chicago.
That is the main problem: although LS9 can produce its bug fuel in laboratory beakers, it has no idea whether it will be able produce the same results on a nationwide or even global scale.
“Our plan is to have a demonstration-scale plant operational by 2010 and, in parallel, we’ll be working on the design and construction of a commercial-scale facility to open in 2011,” says Mr Pal, adding that if LS9 used Brazilian sugar cane as its feedstock, its fuel would probably cost about $50 a barrel.
Are Americans ready to be putting genetically modified bug excretion in their cars? “It’s not the same as with food,” Mr Pal says. “We’re putting these bacteria in a very isolated container: their entire universe is in that tank. When we’re done with them, they’re destroyed.”
Besides, he says, there is greater good being served. “I have two children, and climate change is something that they are going to face. The energy crisis is something that they are going to face. We have a collective responsibility to do this.”
Silicon Valley is experimenting with bacteria that have been genetically altered to provide 'renewable petroleum'
Some diesel fuel produced by genetically modified bugs
Image :1 of 3
Chris Ayres
“Ten years ago I could never have imagined I’d be doing this,” says Greg Pal, 33, a former software executive, as he squints into the late afternoon Californian sun. “I mean, this is essentially agriculture, right? But the people I talk to – especially the ones coming out of business school – this is the one hot area everyone wants to get into.”
He means bugs. To be more precise: the genetic alteration of bugs – very, very small ones – so that when they feed on agricultural waste such as woodchips or wheat straw, they do something extraordinary. They excrete crude oil.
Unbelievably, this is not science fiction. Mr Pal holds up a small beaker of bug excretion that could, theoretically, be poured into the tank of the giant Lexus SUV next to us. Not that Mr Pal is willing to risk it just yet. He gives it a month before the first vehicle is filled up on what he calls “renewable petroleum”. After that, he grins, “it’s a brave new world”.
Mr Pal is a senior director of LS9, one of several companies in or near Silicon Valley that have spurned traditional high-tech activities such as software and networking and embarked instead on an extraordinary race to make $140-a-barrel oil (£70) from Saudi Arabia obsolete. “All of us here – everyone in this company and in this industry, are aware of the urgency,” Mr Pal says.
What is most remarkable about what they are doing is that instead of trying to reengineer the global economy – as is required, for example, for the use of hydrogen fuel – they are trying to make a product that is interchangeable with oil. The company claims that this “Oil 2.0” will not only be renewable but also carbon negative – meaning that the carbon it emits will be less than that sucked from the atmosphere by the raw materials from which it is made.
LS9 has already convinced one oil industry veteran of its plan: Bob Walsh, 50, who now serves as the firm’s president after a 26-year career at Shell, most recently running European supply operations in London. “How many times in your life do you get the opportunity to grow a multi-billion-dollar company?” he asks. It is a bold statement from a man who works in a glorified cubicle in a San Francisco industrial estate for a company that describes itself as being “prerevenue”.
Inside LS9’s cluttered laboratory – funded by $20 million of start-up capital from investors including Vinod Khosla, the Indian-American entrepreneur who co-founded Sun Micro-systems – Mr Pal explains that LS9’s bugs are single-cell organisms, each a fraction of a billionth the size of an ant. They start out as industrial yeast or nonpathogenic strains of E. coli, but LS9 modifies them by custom-de-signing their DNA. “Five to seven years ago, that process would have taken months and cost hundreds of thousands of dollars,” he says. “Now it can take weeks and cost maybe $20,000.”
Because crude oil (which can be refined into other products, such as petroleum or jet fuel) is only a few molecular stages removed from the fatty acids normally excreted by yeast or E. coli during fermentation, it does not take much fiddling to get the desired result.
For fermentation to take place you need raw material, or feedstock, as it is known in the biofuels industry. Anything will do as long as it can be broken down into sugars, with the byproduct ideally burnt to produce electricity to run the plant.
The company is not interested in using corn as feedstock, given the much-publicised problems created by using food crops for fuel, such as the tortilla inflation that recently caused food riots in Mexico City. Instead, different types of agricultural waste will be used according to whatever makes sense for the local climate and economy: wheat straw in California, for example, or woodchips in the South.
Using genetically modified bugs for fermentation is essentially the same as using natural bacteria to produce ethanol, although the energy-intensive final process of distillation is virtually eliminated because the bugs excrete a substance that is almost pump-ready.
The closest that LS9 has come to mass production is a 1,000-litre fermenting machine, which looks like a large stainless-steel jar, next to a wardrobe-sized computer connected by a tangle of cables and tubes. It has not yet been plugged in. The machine produces the equivalent of one barrel a week and takes up 40 sq ft of floor space.
However, to substitute America’s weekly oil consumption of 143 million barrels, you would need a facility that covered about 205 square miles, an area roughly the size of Chicago.
That is the main problem: although LS9 can produce its bug fuel in laboratory beakers, it has no idea whether it will be able produce the same results on a nationwide or even global scale.
“Our plan is to have a demonstration-scale plant operational by 2010 and, in parallel, we’ll be working on the design and construction of a commercial-scale facility to open in 2011,” says Mr Pal, adding that if LS9 used Brazilian sugar cane as its feedstock, its fuel would probably cost about $50 a barrel.
Are Americans ready to be putting genetically modified bug excretion in their cars? “It’s not the same as with food,” Mr Pal says. “We’re putting these bacteria in a very isolated container: their entire universe is in that tank. When we’re done with them, they’re destroyed.”
Besides, he says, there is greater good being served. “I have two children, and climate change is something that they are going to face. The energy crisis is something that they are going to face. We have a collective responsibility to do this.”
Planet X in Our Solar System
Large 'Planet X' May Lurk Beyond Pluto
By Ker Than,LiveScience
Posted: 2008-06-19 17:56:30
Filed Under: Science News
(June 19) - An icy, unknown world might lurk in the distant reaches of our solar system beyond the orbit of Pluto, according to a new computer model.
Getty ImagesNew research has found that a hidden world may exist beyond Pluto. According to a computer model, the world is much bigger than Pluto and could satisfy a hypothesis for a "Planet X." Here, a drawing shows Sedna, an object which could be part of this new world.
The hidden world -- thought to be much bigger than Pluto based on the model -- could explain unusual features of the Kuiper Belt, a region of space beyond Neptune littered with icy and rocky bodies. Its existence would satisfy the long-held hopes and hypotheses for a "Planet X" envisioned by scientists and sci-fi buffs alike.
"Although the search for a distant planet in the solar system is old, it is far from over," said study team member Patryk Lykawka of Kobe University in Japan.
The model, created by Lykawka and Kobe University colleague Tadashi Mukai, is detailed in a recent issue of Astrophysical Journal.
If the new world is confirmed, it would not be technically a planet. Under a controversial new definition adopted by the International Astronomical Union (IAU) last week, it would instead be the largest known "plutoid."
The Kuiper Belt contains many peculiar features that can't be explained by standard solar system models. One is the highly irregular orbits of some of the belt's members.
The most famous is Sedna, a rocky object located three times farther from the sun than Pluto. Sedna takes 12,000 years to travel once around the Sun, and its orbit ranges from 80 to 100 astronomical units (AU). One AU is equal to the distance between the Earth and the Sun.
According to the model, Sedna and other Kuiper Belt oddities could be explained by a world 30 to 70 percent as massive as Earth orbiting between 100 AU and 200 AU from the sun.
By Ker Than,LiveScience
Posted: 2008-06-19 17:56:30
Filed Under: Science News
(June 19) - An icy, unknown world might lurk in the distant reaches of our solar system beyond the orbit of Pluto, according to a new computer model.
Getty ImagesNew research has found that a hidden world may exist beyond Pluto. According to a computer model, the world is much bigger than Pluto and could satisfy a hypothesis for a "Planet X." Here, a drawing shows Sedna, an object which could be part of this new world.
The hidden world -- thought to be much bigger than Pluto based on the model -- could explain unusual features of the Kuiper Belt, a region of space beyond Neptune littered with icy and rocky bodies. Its existence would satisfy the long-held hopes and hypotheses for a "Planet X" envisioned by scientists and sci-fi buffs alike.
"Although the search for a distant planet in the solar system is old, it is far from over," said study team member Patryk Lykawka of Kobe University in Japan.
The model, created by Lykawka and Kobe University colleague Tadashi Mukai, is detailed in a recent issue of Astrophysical Journal.
If the new world is confirmed, it would not be technically a planet. Under a controversial new definition adopted by the International Astronomical Union (IAU) last week, it would instead be the largest known "plutoid."
The Kuiper Belt contains many peculiar features that can't be explained by standard solar system models. One is the highly irregular orbits of some of the belt's members.
The most famous is Sedna, a rocky object located three times farther from the sun than Pluto. Sedna takes 12,000 years to travel once around the Sun, and its orbit ranges from 80 to 100 astronomical units (AU). One AU is equal to the distance between the Earth and the Sun.
According to the model, Sedna and other Kuiper Belt oddities could be explained by a world 30 to 70 percent as massive as Earth orbiting between 100 AU and 200 AU from the sun.
Wednesday, June 18, 2008
Melanoma Cure
Cancer patient recovers after injection of immune cells
By Roger Highfield, Science Editor
Last Updated: 10:01pm BST 18/06/2008
A cancer patient has made a full recovery after being injected with billions of his own immune cells in the first case of its kind, doctors have disclosed.
# A promising step in fight against cancer
# Gene therapy cures dying cancer men for first time
# Search for the jab that can combat cancer
The 52-year-old, who was suffering from advanced skin cancer, was free from tumours within eight weeks of undergoing the procedure.
Doctor's use patient's own immune cells to beat cancer
The case could be a landmark in cancer treatment
After two years he is still free from the disease which had spread to his lymph nodes and one of his lungs.
Doctors took cells from the man's own defence system that were found to attack the cancer cells best, cloned them and injected back into his body, in a process known as "immunotherapy". After two years he is still free from the disease which had spread to his lymph nodes and one of his lungs.
Experts said that the case could mark a landmark in the treatment of cancer.
It raises hopes of a possible new way of fighting the disease, which claims 150,000 lives in Britain every year.
Ed Yong, health information manager at Cancer Research UK, said: "It's very exciting to see a cancer patient being successfully treated using immune cells cloned from his own body. While it's always good news when anyone with cancer gets the all clear, this treatment will need to be tested in large clinical trials to work out how widely it could be used."
However, the treatment could prove extremely expensive and scientists say that more research is needed to prove its effectiveness.
Genetically altered white blood cells have been used before to treat cancer patients but this is the first study to show that simply growing vast numbers of the few immune cells in the body to attack a cancer can be safe and effective.
advertisement
Normally there are too few of the cells in a patient's body to effectively fight cancer.
Dr Cassian Yee, who led the team at the Fred Hutchinson Cancer Research Centre in Seattle, said: "For this patient we were successful, but we would need to confirm the effectiveness of therapy in a larger study."
The work raises hopes that this approach could not only offer a more effective treatment for skin cancer, or melanoma, which kills around 2,000 people in Britain alone, but be applied to other cancers too.
The patient was one of nine with metastatic melanoma, that is skin cancer that has spread, who were being treated in a recently completed clinical trial to test bigger and bigger doses of their own white blood cells.
Larger, more elaborate, trials are now under way.
Almost 9,000 new cases of melanoma, the most serious form of skin cancer, are diagnosed every year in Britain, and nearly 2,000 patients die from the disease.
Prof Peter Johnson, Cancer Research UK's chief clinician, said: "This is another interesting demonstration of the huge power of the immune system to fight some types of cancer.
"Although the technique is complex and difficult to use for all but a few patients, the principle that someone's own immune cells can be expanded and made to work in this way is very encouraging for the work that Cancer Research UK and others are carrying out."
Immunotherapy, in which a patients own immune cells are used to treat cancer, is a growing area of research that aims to develop less-toxic treatments than standard chemotherapy and radiation.
Because cancer occurs when the body's own cells grow out of control, the immune system only responds weakly.
The ability of the body's own defences to tackle cancer in this case is all the more remarkable because most deadly feature of the disease is its ability to colonise other parts of the body, when it becomes much more difficult to treat.
A dramatic example of immunotherapy was reported two years ago by one pioneer of the field, Dr Steven Rosenberg of the US National Cancer Institute, who eradicated cancer from two dying men using genetically modified versions of their own cells.
Both Mark Origer and "Thomas M" were suffering from advanced melanoma but the hope is that such methods could be customised to attack other common cancers, notably breast, colon and lung.
Dr Rosenberg told The Daily Telegraph the new work is an "interesting study that helps to confirm the effectiveness of cell transfer immunotherapy for treating cancer patients. We have now treated 93 patients with metastatic melanoma using their own anti-tumour cells with response rates up to 72 per cent. Mark Origer remains disease free now over three years after treatment."
By Roger Highfield, Science Editor
Last Updated: 10:01pm BST 18/06/2008
A cancer patient has made a full recovery after being injected with billions of his own immune cells in the first case of its kind, doctors have disclosed.
# A promising step in fight against cancer
# Gene therapy cures dying cancer men for first time
# Search for the jab that can combat cancer
The 52-year-old, who was suffering from advanced skin cancer, was free from tumours within eight weeks of undergoing the procedure.
Doctor's use patient's own immune cells to beat cancer
The case could be a landmark in cancer treatment
After two years he is still free from the disease which had spread to his lymph nodes and one of his lungs.
Doctors took cells from the man's own defence system that were found to attack the cancer cells best, cloned them and injected back into his body, in a process known as "immunotherapy". After two years he is still free from the disease which had spread to his lymph nodes and one of his lungs.
Experts said that the case could mark a landmark in the treatment of cancer.
It raises hopes of a possible new way of fighting the disease, which claims 150,000 lives in Britain every year.
Ed Yong, health information manager at Cancer Research UK, said: "It's very exciting to see a cancer patient being successfully treated using immune cells cloned from his own body. While it's always good news when anyone with cancer gets the all clear, this treatment will need to be tested in large clinical trials to work out how widely it could be used."
However, the treatment could prove extremely expensive and scientists say that more research is needed to prove its effectiveness.
Genetically altered white blood cells have been used before to treat cancer patients but this is the first study to show that simply growing vast numbers of the few immune cells in the body to attack a cancer can be safe and effective.
advertisement
Normally there are too few of the cells in a patient's body to effectively fight cancer.
Dr Cassian Yee, who led the team at the Fred Hutchinson Cancer Research Centre in Seattle, said: "For this patient we were successful, but we would need to confirm the effectiveness of therapy in a larger study."
The work raises hopes that this approach could not only offer a more effective treatment for skin cancer, or melanoma, which kills around 2,000 people in Britain alone, but be applied to other cancers too.
The patient was one of nine with metastatic melanoma, that is skin cancer that has spread, who were being treated in a recently completed clinical trial to test bigger and bigger doses of their own white blood cells.
Larger, more elaborate, trials are now under way.
Almost 9,000 new cases of melanoma, the most serious form of skin cancer, are diagnosed every year in Britain, and nearly 2,000 patients die from the disease.
Prof Peter Johnson, Cancer Research UK's chief clinician, said: "This is another interesting demonstration of the huge power of the immune system to fight some types of cancer.
"Although the technique is complex and difficult to use for all but a few patients, the principle that someone's own immune cells can be expanded and made to work in this way is very encouraging for the work that Cancer Research UK and others are carrying out."
Immunotherapy, in which a patients own immune cells are used to treat cancer, is a growing area of research that aims to develop less-toxic treatments than standard chemotherapy and radiation.
Because cancer occurs when the body's own cells grow out of control, the immune system only responds weakly.
The ability of the body's own defences to tackle cancer in this case is all the more remarkable because most deadly feature of the disease is its ability to colonise other parts of the body, when it becomes much more difficult to treat.
A dramatic example of immunotherapy was reported two years ago by one pioneer of the field, Dr Steven Rosenberg of the US National Cancer Institute, who eradicated cancer from two dying men using genetically modified versions of their own cells.
Both Mark Origer and "Thomas M" were suffering from advanced melanoma but the hope is that such methods could be customised to attack other common cancers, notably breast, colon and lung.
Dr Rosenberg told The Daily Telegraph the new work is an "interesting study that helps to confirm the effectiveness of cell transfer immunotherapy for treating cancer patients. We have now treated 93 patients with metastatic melanoma using their own anti-tumour cells with response rates up to 72 per cent. Mark Origer remains disease free now over three years after treatment."
Tuesday, June 17, 2008
Earth-like Planets May Be Very Common
Astronomers find batch of "super-Earths"
Mon Jun 16, 7:53 AM ET
WASHINGTON (Reuters) - European researchers said on Monday they discovered a batch of three "super-Earths" orbiting a nearby star, and two other solar systems with small planets as well.
They said their findings, presented at a conference in France, suggest that Earth-like planets may be very common.
"Does every single star harbor planets and, if yes, how many?" asked Michel Mayor of Switzerland's Geneva Observatory. "We may not yet know the answer but we are making huge progress towards it," Mayor said in a statement.
The trio of planets orbit a star slightly less massive than our Sun, 42 light-years away towards the southern Doradus and Pictor constellations. A light-year is the distance light can travel in one year at a speed of 186,000 miles a second, or about 6 trillion miles.
The planets are bigger than Earth -- one is 4.2 times the mass, one is 6.7 times and the third is 9.4 times.
They orbit their star at extremely rapid speeds -- one whizzing around in just four days, compared with Earth's 365 days, one taking 10 days and the slowest taking 20 days.
Mayor and colleagues used the High Accuracy Radial velocity Planet Searcher or HARPS, a telescope at La Silla observatory in Chile, to find the planets.
More than 270 so-called exoplanets have been found. Most are giants, resembling Jupiter or Saturn. Smaller planets closer to the size of Earth are far more difficult to spot.
None can be imaged directly at such distances but can be spotted indirectly using radio waves or, in the case of HARPS, spectrographic measurements. As a planet orbits, it makes the star wobble very slightly and this can be measured.
"With the advent of much more precise instruments such as the HARPS spectrograph ... we can now discover smaller planets, with masses between 2 and 10 times the Earth's mass," said Stephane Udry, who also worked on the study.
The team also said they found a planet 7.5 times the mass of Earth orbiting the star HD 181433 in 9.5 days. This star also has a Jupiter-like planet that orbits every three years.
Another solar system has a planet 22 times the mass of Earth, orbiting every four days, and a Saturn-like planet with a 3-year period.
"Clearly these planets are only the tip of the iceberg," said Mayor.
"The analysis of all the stars studied with HARPS shows that about one third of all solar-like stars have either super-Earth or Neptune-like planets with orbital periods shorter than 50 days."
(Reporting by Maggie Fox; Editing by John O'Callaghan)
Mon Jun 16, 7:53 AM ET
WASHINGTON (Reuters) - European researchers said on Monday they discovered a batch of three "super-Earths" orbiting a nearby star, and two other solar systems with small planets as well.
They said their findings, presented at a conference in France, suggest that Earth-like planets may be very common.
"Does every single star harbor planets and, if yes, how many?" asked Michel Mayor of Switzerland's Geneva Observatory. "We may not yet know the answer but we are making huge progress towards it," Mayor said in a statement.
The trio of planets orbit a star slightly less massive than our Sun, 42 light-years away towards the southern Doradus and Pictor constellations. A light-year is the distance light can travel in one year at a speed of 186,000 miles a second, or about 6 trillion miles.
The planets are bigger than Earth -- one is 4.2 times the mass, one is 6.7 times and the third is 9.4 times.
They orbit their star at extremely rapid speeds -- one whizzing around in just four days, compared with Earth's 365 days, one taking 10 days and the slowest taking 20 days.
Mayor and colleagues used the High Accuracy Radial velocity Planet Searcher or HARPS, a telescope at La Silla observatory in Chile, to find the planets.
More than 270 so-called exoplanets have been found. Most are giants, resembling Jupiter or Saturn. Smaller planets closer to the size of Earth are far more difficult to spot.
None can be imaged directly at such distances but can be spotted indirectly using radio waves or, in the case of HARPS, spectrographic measurements. As a planet orbits, it makes the star wobble very slightly and this can be measured.
"With the advent of much more precise instruments such as the HARPS spectrograph ... we can now discover smaller planets, with masses between 2 and 10 times the Earth's mass," said Stephane Udry, who also worked on the study.
The team also said they found a planet 7.5 times the mass of Earth orbiting the star HD 181433 in 9.5 days. This star also has a Jupiter-like planet that orbits every three years.
Another solar system has a planet 22 times the mass of Earth, orbiting every four days, and a Saturn-like planet with a 3-year period.
"Clearly these planets are only the tip of the iceberg," said Mayor.
"The analysis of all the stars studied with HARPS shows that about one third of all solar-like stars have either super-Earth or Neptune-like planets with orbital periods shorter than 50 days."
(Reporting by Maggie Fox; Editing by John O'Callaghan)
Subscribe to:
Posts (Atom)
